Tehran University of Medical Sciences
Design and synthesis of new 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles as anticonvulsant agents.
Authors: Zarghi A , Hajimahdi Z , Mohebbi S , Rashidi H , Mozaffari S , Sarraf S , Faizi M , Tabatabaee SA , Shafiee A ,
Chemical & pharmaceutical bulletin , Vol., No. 0009-2363 (Print) , 20080401 ,Page:0
A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism.