Tehran University of Medical Sciences
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Abbas Shafiee

Synthesis and antibacterial activity of nitroaryl thiadiazole-levofloxacin hybrids.


Authors: Foroumadi A , Mansouri S , Emami S , Mirzaei J , Sorkhi M , Saeid-Adeli N , Shafiee A ,
Archiv der Pharmazie , Vol., No. 0365-6233 (Print) , 20061030 ,Page:0
Novel levofloxacin-containing hybrids carrying a 5-(nitroaryl)-1,3,4-thiadiazol-2-yl group were synthesized and evaluated in vitro against Gram-positive and Gram-negative bacteria. Preliminary data indicated that levofloxacin-nitrofuran and levofloxacin-nitroimidazole hybrids have a potent activity against Gram-positive organisms with enhanced anti-staphylococcal activity compared with the parent quinolone (N-desmethyl levofloxacin).