Tehran University of Medical Sciences
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Abbas Shafiee

Synthesis and antibacterial activity of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones.


Authors: Tehranchian S , Akbarzadeh T , Fazeli MR , Jamalifar H , Shafiee A ,
Bioorganic & medicinal chemistry letters , Vol., No. 0960-894X (Print) , 20050202 ,Page:0
A series of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones were synthesized and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a good activity against Staphylococcus aureus, S. epidermidis and Bacillus subtilis.