Tehran University of Medical Sciences
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Abbas Shafiee

Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles.

Authors: Almasirad A , Tabatabai SA , Faizi M , Kebriaeezadeh A , Mehrabi N , Dalvandi A , Shafiee A ,
Bioorganic & medicinal chemistry letters , Vol., No. 0960-894X (Print) , 20041119 ,Page:0
A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.