Tehran University of Medical Sciences
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Abbas Shafiee

Microbial hydroxylation of progesterone with Acremonium strictum.


Authors: Faramarzi MA , Tabatabaei Yazdi M , Amini M , Zarrini G , Shafiee A ,
FEMS microbiology letters , Vol., No. 0378-1097 (Print) , 20030528 ,Page:0
Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15alpha-hydroxyprogesterone and 15alpha-hydroxydeoxycorticosterone.