Tehran University of Medical Sciences
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Abbas Shafiee

Synthesis and antagonistic activity of four new 2-alkyl-N-biphenyl fused imidazoles on angiotensin II receptors.


Authors: Akhavan MM , Mojarrad JS , Rouzrokh A , Ebrahimi SA , Mahmoudian M , Shafiee A ,
Farmaco (Societa chimica italiana : 1989) , Vol., No. 0014-827X (Print) , 20031023 ,Page:0
In the current study, four new 2-alkyl-N-biphenyl fused imidazoles were synthesized and the pharmacological properties of these compounds as angiotensin II antagonists were studied. First, the potency of the synthesized compounds on guinea-pig ileum was evaluated and the vasopressor effect of the most potent compound 6a was compared with losartan on isolated perfused rat kidney. The antagonistic activity of compound 6a (sodium 2-propyl-5-carbomethoxy-1-[(biphenyl-4-yl)methyl]pyrrolo[3,2-d]imidazole-2'-carbo xylate) on angiotensin II receptors was greater than the other synthesized compounds and in isolated perfused rat kidney was similar to losartan.