Tehran University of Medical Sciences
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Abbas Shafiee

Synthesis and anti-inflammatory activity of new 1-methyl-4-(4-X-benzenesulfonyl)pyrrolo[2,3-d] imidazole-5-carboxylates.


Authors: Zarghi A , Ebrahimabadi AH , Hassanzadeh F , Heydari MR , Shafiee A ,
Bollettino chimico farmaceutico , Vol., No. 0006-6648 (Print) , 20031110 ,Page:0
A series of 1-methyl-4-(4-X-arylsulfonyl)pyrrolo[2,3-d]imidazo-le-5-carboxylates were synthesized and tested as anti-inflammatory agents. Indomethacin was used as reference drug. Two of the synthesized compounds 7a and 7b had an effect equal to 0.1 of indomethacin. Our result showed that the electron-withdrawing substituents in the para position of the benzensulfonyl moiety increase activity.