Tehran University of Medical Sciences
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Abbas Shafiee

Synthesis and antihypertensive activity of 1-(2-thiazolyl)-3, 5-disubstituted -2-pyrazolines.


Authors: Bagheri M , Shekarchi M , Jorjani M , Ghahremani MH , Vosooghi M , Shafiee A ,
Archiv der Pharmazie , Vol., No. 0365-6233 (Print) , 20040204 ,Page:0
Several substituted 3-aryl-1-(4-aryl-2-thiazolyl)-5-(3-pyridyl)-2-pyrazolines were synthesized by reacting substituted 3-aryl-5-(3-pyridyl)-1-thiocarbamoyl-2-pyrazolines with phenacyl bromide in ethanol. The structures of all compounds were confirmed by IR, (1)H-NMR, mass spectral data and elemental analyses. The antihypertensive activity of compounds was examined by the tail-cuff method and compared with clonidine. Compounds 24-28 showed significant antihypertensive activity.