Tehran University of Medical Sciences
Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole.
Authors: Jalilian AR , Rowshanfarzad P , Afarideh H , Shafiee A , Sabet M , Kyoumarsi M , Raisali GR ,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine , Vol., No. 0969-8043 (Print) , 20040414 ,Page:0
Selenium-75 (t1/2 = 120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35 microCi/microAh; maximum current, 6 microA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50 degrees C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.