Tehran University of Medical Sciences
Synthesis and in vitro antimicrobial evaluation of 5-(1-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles.
Authors: Shafiee A , Sayadi A , Roozbahani MH , Foroumadi A , Kamal F ,
Archiv der Pharmazie , Vol., No. 0365-6233 (Print) , 20021230 ,Page:0
The increasing clinical importance of drug-resistant pathogens has lent additional urgency to antimicrobial research. Various 5-(1-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles (4a-6f) were synthesized and tested in vitro for their antibacterial and antifungal activities. Compounds 4a and 4b exhibited significant effects against Bacillus subtilis at MIC ranges of 0.5-1 microg/mL and moderate effects against Staphylococcus aureus.