Tehran University of Medical Sciences
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Abbas Shafiee

Long-acting contraceptive agents: esters of norethisterone with alpha- and/or beta-chain branching.

Authors: Watson TG , Hosking M , Herz JE , Torres JV , Muller J , Murillo A , Cruz S , Shafiee A , Vossoghi M , Savabi F , et al. ,
Steroids , Vol., No. 0039-128X (Print) , 19840214 ,Page:0
The synthesis of eighteen esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) is described. These all possess some form of alpha- and/or beta-substitution in the ester side-chain. The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds. A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern.