Tehran University of Medical Sciences
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Mohammad Hossein Nekoofar

Evaluation of meloxicam (A cox-2 inhibitor) for management of postoperative endodontic pain: a double-blind placebo-controlled study

Authors: Nekoofar, M. H. - Sadeghipanah, M. - Dehpour, A. R. -
Keywords: Adult , Analysis of Variance , Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use , Chi-Square Distribution , Cyclooxygenase 2 , Cyclooxygenase 2 Inhibitors , Cyclooxygenase Inhibitors/*therapeutic use , Double-Blind Method , Humans , Isoenzymes/antagonists & inhibitors , Membrane Proteins , Pain Measurement , Pain, Postoperative/etiology/*prevention & control , Piroxicam/therapeutic use , Prostaglandin-Endoperoxide Synthases , Regression Analysis , Root Canal Therapy/*adverse effects , Thiazines/*therapeutic use , Thiazoles/*therapeutic use , Toothache/etiology/*prevention & control ,
J Endod, Vol.29, No.10, 2003,Page:634-7
Successful management of endodontic pain represents a continuing challenge. The purpose of this randomized, double-blind, placebo-controlled, parallel-group trial was to compare the pain reducing effect of oral preparations of meloxicam, piroxicam, and placebo in endodontic emergency patients. A total of 51 patients who presented to the Tehran University endodontic clinic and one private dental clinic were invited to participate. Patients were asked to evaluate their pretreatment pain with a visual-analog scale. After root canal therapy they were randomly assigned to one of three groups: meloxicam, piroxicam, or placebo. Each patient was sent home with a visual-analog scale to fill out at 8 and 24 h after completion of therapy. The results of this study showed no significant differences between efficacy of meloxicam, piroxicam, and placebo, but a significant effect of the time factor in reducing postoperative pain in all treatment groups was observed.