Tehran University of Medical Sciences
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Davood Beiki

Synthesis of radioiodinated labeled peptides

Authors: Matloobi M, Rafii H, Beiki D, Khalaj A, Kamali-Dehghan M,
J Radioanal Nucl Chem , Vol.257, No.1, 2003,Page:71-73

This report covers optimization of radioiodination of peptides by both a direct method in which a constituent tyrosine residue is labeled and indirect method by using an iodinated derivative (SIB) of N succinimidyl 3-(tri-n-butylstannyl) benzoate (ATE) as the intermediate. Radioiodination of IgG and FMLF were performed by direct method using Chloramine-T as an oxidant but since Formyl-Methyl-Leucyl-Phenylalanine, FMLF, does not lend itself for direct radioiodination we performed labeling of FMLF by indirect method via radioiodined SIB at different pH.