A simple, rapid and specific high-performance liquid chromatographic procedure is reported forquantitative determination of dipyridamole in human -plasma. The assay uses a reversed-phasehigh-performance liquid chromatographic (HPLC) and UV detection at 280nm and has a limitof detection of approximately 5ng/mL. The mobile phase consists of MeOH-H20 (60:40)adjusted to pH 3.3. Dipyridamole was extracted from plasma by back-extraction procedure, withpropranolol as the internal standard. The reproducibility of the method is satisfactory.
Tehran University of Medical Sciences
High performance liquid chromatographic method for determination of dipyridamole in human plasma
Authors: Beiki D, Pirali M, Amini M, Shafiee A,
DARU, Vol.7, No.2, 1999,Page:14-17